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Evaluation of the Digital Support Tool Gro Health W8Buddy as Part of Tier 3 Weight Management Service: Observational Study

Evaluation of the Digital Support Tool Gro Health W8Buddy as Part of Tier 3 Weight Management Service: Observational Study

In the United Kingdom, 25% of men and 26% of women live with obesity [1]. Overweight and obesity are more prevalent in people living in the most deprived areas compared to the least deprived areas (72% and 58%, respectively) [1]. Similarly, excess weight disproportionately affects people in the Black ethnic group (72% compared to 64% in people from the White ethnic group) [1].

Petra Hanson, Farah Abdelhameed, Mohammed Sahir, Nick Parsons, Arjun Panesar, Michaela de la Fosse, Charlotte Summers, Amit Kaura, Harpal Randeva, Vinod Menon, Thomas M Barber

J Med Internet Res 2025;27:e62661


Metabolic Flexibility to Predict Lifestyle Interventions Outcomes (MEPHISTO): Protocol for Predictive Validation Study and Randomized Controlled Trial

Metabolic Flexibility to Predict Lifestyle Interventions Outcomes (MEPHISTO): Protocol for Predictive Validation Study and Randomized Controlled Trial

Obesity has reached pandemic proportions and is a major risk factor for type 2 diabetes (T2 D), cardiovascular disease, and other metabolic disorders. Prevention progression to T2 D in individuals with obesity through effective lifestyle interventions is a public health priority Substantial and sustained weight loss achieved through lifestyle modifications is a key strategy to reduce the risk of T2 D and improve metabolic health [1,2].

Monika Ludlova, Kateřina Koudelková, Jitka Pallova, Barbora Koudelkova, Michaela Siklova, Monika Cahova, Tomas Vetrovsky, Michal Steffl, Jan Gojda

JMIR Res Protoc 2025;14:e67570


The Role of Mobile Apps in Obesity Management: Systematic Review and Meta-Analysis

The Role of Mobile Apps in Obesity Management: Systematic Review and Meta-Analysis

Obesity represents one of the major public health challenges of the 21st century. The World Health Organization [1] defines obesity as an abnormal or excessive accumulation of fat that may impair health. Globally, the prevalence of people with obesity is rising steadily, which is a big problem for health, economy, and society. In the United States, projections show that by 2050, the number of adults who are overweight or obese will increase from 172 million in 2021 to 213 million.

Carmelo Pujia, Yvelise Ferro, Elisa Mazza, Samantha Maurotti, Tiziana Montalcini, Arturo Pujia

J Med Internet Res 2025;27:e66887


The Impact of Technology-Enabled Medical Nutrition Therapy on Weight Loss in Adults With Overweight and Obesity: Retrospective Observational Study

The Impact of Technology-Enabled Medical Nutrition Therapy on Weight Loss in Adults With Overweight and Obesity: Retrospective Observational Study

Obesity remains a critical public health challenge nationwide, affecting over 100 million adults across the United States according to recent estimates [1]. In the United States, the prevalence of obesity has continued to rise, with over 40% of adults classified as obese in 2023 [2] and rates expected to exceed 60% in 2050, posing a significant public health threat given its impact on the existing chronic disease epidemic [3].

Emily A Hu, Tommy Kelley, Ajay Haryani

JMIR Mhealth Uhealth 2025;13:e70228


Acceptability of and Willingness to Use Virtual Reality Exergames for Weight Loss Among Young Adults With Overweight or Obesity in China: Qualitative Study

Acceptability of and Willingness to Use Virtual Reality Exergames for Weight Loss Among Young Adults With Overweight or Obesity in China: Qualitative Study

The epidemic of obesity or overweight has gone beyond being a cosmetic concern to become a disease that poses a substantial threat to the well-being of individuals worldwide. Obesity raises the likelihood of developing a series of diseases, such as diabetes, hypertension, arteriosclerosis, hyperlipidemia, cardiovascular disease, and specific types of cancer [1]. Individuals with obesity also grapple with psychological disorders, including depression, lack of self-confidence, and low self-efficacy [2].

Yanya Chen, Bingsheng Guan, Yaqi Zhang, Suen Chow Lee, Jia-yu Liu, Sicun Li, Ming Liu, Xiaoshen Zhang, Wai-kit Ming

JMIR Serious Games 2025;13:e66998


Improving Diet Quality of People Living With Obesity by Building Effective Dietetic Service Delivery Using Technology in a Primary Health Care Setting: Protocol for a Randomized Controlled Trial

Improving Diet Quality of People Living With Obesity by Building Effective Dietetic Service Delivery Using Technology in a Primary Health Care Setting: Protocol for a Randomized Controlled Trial

The high and increasing prevalence of obesity across the world is a major challenge for health care delivery and confers a substantial burden on individuals and the health care sector. The effects of obesity are widely recognized as one of the leading health concerns, affecting all age and socioeconomic groups [1].

Deborah A Kerr, Clare E Collins, Andrea Begley, Barbara Mullan, Satvinder S Dhaliwal, Claire E Pulker, Fengqing Zhu, Marie Fialkowski, Richard L Prince, Richard Norman, Anthony P James, Paul Aveyard, Helen Mitchell, Jacquie Garton-Smith, Megan E Rollo, Chloe Maxwell-Smith, Amira Hassan, Hayley Breare, Lucy M Butcher, Christina M Pollard

JMIR Res Protoc 2025;14:e64735


Telemedicine Booths for Screening Cardiovascular Risk Factors: Prospective Multicenter Study

Telemedicine Booths for Screening Cardiovascular Risk Factors: Prospective Multicenter Study

There are several well-known modifiable risk factors for CVD, including obesity, high blood pressure, and physical inactivity [5]. The most significant of these is hypertension because it accounts for the largest number of CVD deaths [5,6]. In France, this affects around 22% of the population, but over a third are unaware that they have the condition because there are usually no symptoms [4,7].

Mélanie Decambron, Christine Tchikladze Merand

JMIR Hum Factors 2025;12:e57032


Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

The offspring of mothers with pre-existing metabolic diseases—obesity, diabetes, and hypertension—have an increased risk of significant congenital anomalies and premature birth compared with the offspring of mothers without metabolic disease [1]. These offspring are also twice as likely to develop obesity, diabetes, and hypertension in childhood [2].

Sarah A L Price, Digsu N Koye, Alice Lewin, Alison Nankervis, Stefan C Kane

JMIR Res Protoc 2025;14:e72542


Association of Social Media Recruitment and Depression Among Racially and Ethnically Diverse Metabolic and Bariatric Surgery Candidates: Prospective Cohort Study

Association of Social Media Recruitment and Depression Among Racially and Ethnically Diverse Metabolic and Bariatric Surgery Candidates: Prospective Cohort Study

Over the past 2 decades, obesity (ie, BMI ≥30 kg/m2) prevalence among adults in the United States has risen from 30.5% to 42.4% [1], and has nearly tripled worldwide [2]. Further, the prevalence of severe obesity (BMI ≥40 kg/m2) has doubled from 4.7% to 9.2% [3]. Non-Hispanic Black (NHB) adults are disproportionately impacted, with an age-adjusted obesity prevalence of 49.9%, followed by Hispanic (45.6%), non-Hispanic White (NHW) (41.4%), and non-Hispanic Asian (16.1%) individuals [3].

Jackson M Francis, Sitapriya S Neti, Dhatri Polavarapu, Folefac Atem, Luyu Xie, Olivia Kapera, Matthew S Mathew, Elisa Marroquin, Carrie McAdams, Jeffrey Schellinger, Sophia Ngenge, Sachin Kukreja, Benjamin E Schneider, Jaime P Almandoz, Sarah E Messiah

JMIR Form Res 2025;9:e58916


Large-Scale Evaluation and Liver Disease Risk Prediction in Finland’s National Electronic Health Record System: Feasibility Study Using Real-World Data

Large-Scale Evaluation and Liver Disease Risk Prediction in Finland’s National Electronic Health Record System: Feasibility Study Using Real-World Data

The burden of liver disease increases yearly in Finland because the Finnish population age average grows, and obesity and overweight are more common problems in the Finnish population [1]. On average, there are 1000 deaths caused by alcoholic liver disease every year [2]. For the early detection of individuals from the general population at high risk for future severe liver disease, the CLiv D (Chronic Liver Disease score) score was developed.

Viljami Männikkö, Janne Tommola, Emmi Tikkanen, Olli-Pekka Hätinen, Fredrik Åberg

JMIR Med Inform 2025;13:e62978